Injikovatelný hydrogel funkcionalizovaný suspenzí bohatou na trombocyty a mikročásticemi pro urychlení regenerace chrupavky
نویسندگان
چکیده
PURPOSE OF THE STUDY Articular cartilage defects arise due to injury or osteochondral disease such as osteonecrosis or osteochondritis dissecans. In adult patients cartilage has minimal ability to repair itself and the lesions develop into degenerative arthritis. Overcoming the low regenerative capacity of the cartilage cells and the Hayflick limit poses a challenge for the therapy of osteochondral defects. Composite scaffolds with appropriate biomechanical properties combined with a suitable blend of proliferation and differentiation factors could be a solution. The aim of this in vitro study was to develop a novel functionalised hydrogel with an integrated drug delivery system stimulating articular cartilage regeneration.
منابع مشابه
Synthesis and Swelling Behavior of Gelatin-Based Hydrogel Nanocomposites
In this work, a series of hydrogel nanocomposites were prepared by grafting acrylic acid and acrylamide on gelatin in the presence of Na-montmorillonite (Na-MMT) nanoparticles. The characterizations of hydrogel nanocomposites were examined by swelling experiments, Fourier transform infrared (FT-IR) spectroscopy, X-Ray diffraction (XRD) patterns and thermogravimetric analysis (TGA). Scanning ele...
متن کاملDynamic Visualization in Transport Domain Dynamická Vizualizace V Oblasti Dopravy
Cartography as a discipline with a rich history, analogously to other sciences, went during last years through a tremendous development, namely especially due to rapid advances in technologies. The digital technologies cause changes virtually in all scientific disciplines, not excepting cartography. In the field of cartography they bring new methods of data processing and new ways of presentati...
متن کاملThe Adsorption of Polyacrylamide Nanocomposite Hydrogels on Sandstone
A key parameter for the application of polymer gels in water shut off treatment is the adsorption of polymer gel onto the rock surface. So, the adsorption properties of a nanocomposite hydrogel were discussed in this research by crosslinking of sulfonated polyacrylamide/sodium montmorillonite aqueous solutions with chromium triacetate. The X-ray diffraction patterns indicated that exfoliated ty...
متن کاملControlled proliferation and screening of mammalian cells on a hydrogel-functionalized small molecule microarray.
A hydrogel-functionalized small molecule microarray has been developed, on which PC-3 cancer cells were selectively grown. Subsequent controlled release of immobilized bioactive compounds enabled cell-based screening to be directly carried out on this platform.
متن کاملThermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model
Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, which combined the anti-adhesion barrier with controlled release of anti-adhesion drug. Dexamethasone (Dex) was encapsulated in polymeric micelles (Dex micelles), and then the Dex micelles were loaded into biodegradabl...
متن کامل